Endocrine Abstracts

Objectives: To evaluate the efficacy of growth hormone (GH) treatment in children with Turner syndrome (TS) and to analyze the factors affecting the success of treatment.Methods: Retrospective observational study was conducted for 62 patients with TS. 3 groups of patients were identified: group 1 with karyotype 45, X (n=32), group 2 with mosaic variant 45,X/46,XX (n=8), group 3 with structural anomalies of X chromosome (n=22). ...

Aim: To evaluate bone mineral density (BMD) in children with different karyotype variants of Turner syndrome (TS) depending on the stage and the onset of puberty (spontaneous or induced).Methods: The total studied group consisted of 75 children with TS from 8 to 17 years (mean age 14.2 ± 2.61), who were regularly followed-up in the University hospital (Minsk) and age matched 25 healthy controls. TS was diagnosed according to the results of karyotypi...

Objectives: To evaluate the prevalence and characteristics of thyroid diseases in children with Turner syndrome (TS).Methods: This is a retrospective study, analyzing clinical data from medical records of 19 patients with TS from 3 to 17 years (average age 12.02±4.0 years), who were regularly followed-up in the University hospital (Minsk). Depending on the karyotype, 3 groups of patients were identified: the first group with karyotype 45, X (n</...

IntroductionTurner syndrome (TS) is usually accompanied by hyperhonadotroic hypogonadism and primary amenorrhea due to gonadal disgenesis. One-third of girls with TS have spontaneous thelarhe (ST). Regular menstrual cycles occur in at most 6% of this patients.ObjectivesTo analyze the characteristics of pubertal development in children with different karyotype variants of TS.Methods<...

Introduction: The prevalence of autoimmune thyroid diseases in patients with type 1 diabetes mellitus (T1DM) is high. Thyroid hormones have a pronounced effect on the regulation of glucose homeostasis. We report patient with well controlled T1DM and good compliance, presented with severe diabetic ketoacidosis (DKA) due to thyrotoxicosis.Case report: A 15-year-old girl with well-controlled T1DM for 5 years (HbA1c<8%) had no tissue complications of dia...

Introduction: Autoimmune polyglandular syndrome type 1 (APS1) – severe disease that is rare in pediatric practice. Clinical sings of APS1 are quite diverse, new components may manifest at any age. Their timely diagnosis is critically important, some symptoms can threaten patient’s life. We present our own clinical observation of the APS1 course in siblings.Case report: A 10-year-old previously healthy boy presented with severe weakness, drowsin...